The significant advances in healthy care and quality of life during the last seven decades have resulted in an increase in the incidence of age-related neurodegenerative diseases. In the brain, cell adhesion molecules (CAMs) are involved in neurogenesis, neurite outgrowth, target recognition during synaptogenesis and in the stability of synapses. Mutations in or impairment of CAM functionality are associated with neurologic and psychiatric diseases. The coxsackievirus adenovirus receptor (CAR) is a type I transmembrane protein belonging to the Ig superfamily. CAR is expressed in neurons throughout the brain, but its physiological function is poorly characterized. We found that CAR loss of function - induced genetically or via an inflammatory response - in the neurogenic niches is linked with perturbed neurogenesis, behaviour, LTP and synapse content. Our goal is to better understand the role of CAR in the healthy and diseased brain, especially related to cognitive impairment.
E Kremer1919 route de Mende
IGMM CNRS 5535