We are looking for an excellent and highly motivated PhD student (m/f) in cellular neuroscience. In this research project you will make electrophysiological recordings of single neurons and their subcellular domains, the pre- and postsynaptic targets and combine electrical characterization with optogenetic activation of cortical circuits. Furthermore, the cellular recordings will be complemented with micro- and nanoscopic analysis of synapse anatomy and will be linked to in vivo recordings and behavior. The overall aim of the project is to understand the role of the immune-mediated changes in neural circuits identified in patients with multiple sclerosis. For literature see for example Battefeld et al. Nat Commun 7 (2016), Hamada and Kole, J Neurosci 35 (2015) or Michailidou et al., Ann Neurol. 77 (2015). We offer a state-of-the-art research infrastructure based at the Netherlands Institute for Neurosciences, Amsterdam, a prestigious research institute of the Royal Netherlands Academy for Arts and Sciences (KNAW). Our group is associated with the Cellular Biology department at the University of Utrecht (UU). This specific PhD project is conducted within an exciting network of national (VuMC, human brain bank) and international collaborators in Germany, UK and the United States and funded by the National MS Society (USA). Suitable candidates will have a MSc or equivalent degree in biology, medicine, biophysics or a related discipline. You will have extensive experience and background in cellular electrophysiology, demonstrated written and spoken English proficiency and excellent communication skills. Affinity with animal models for disease will be considered as an advantage. Please send your CV with two names of references by e-mail.
Maarten KoleNetherlands institute for Neuroscience,
1105 BA, Amsterdam,